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Bristol-Myers Squibb
Bristol-Myers Squibb
(BMS) is an American pharmaceutical company, headquartered in New York City. Bristol-Myers Squibb
Bristol-Myers Squibb
manufactures prescription pharmaceuticals in several therapeutic areas, including cancer, HIV/AIDS, cardiovascular disease, diabetes, hepatitis, rheumatoid arthritis and psychiatric disorders. BMS' primary R&D sites are located in Lawrence, New Jersey (formerly Squibb, near Princeton) and Wallingford, Connecticut (formerly Bristol-Myers); with other sites in East Syracuse, New York; Princeton Pike, Hopewell Township and New Brunswick, New Jersey; and in Swords, Ireland; Braine-l'Alleud, Belgium; Tokyo, Japan; and Bangalore, India.[2]

Contents

1 History

1.1 Squibb 1.2 Bristol-Myers 1.3 Merger 1.4 2000 to 2010 1.5 2011 onward 1.6 Acquisition history

2 Pharmaceuticals

2.1 Out of production 2.2 Divested brands

3 Products under development 4 See also 5 Notes and references 6 External links

History[edit] Squibb[edit] The Squibb corporation was founded in 1858 by Edward Robinson Squibb in Brooklyn, New York. Squibb was known as a vigorous advocate of quality control and high purity standards within the fledgling pharmaceutical industry of his time, at one point self-publishing an alternative to the U.S. Pharmacopeia (Squibb's Ephemeris of Materia Medica) after failing to convince the American Medical Association
American Medical Association
to incorporate higher purity standards. Mentions of the Materia Medica, Squibb products, and Edward Squibb's opinion on the utility and best method of preparation for various medicants are found in many medical papers of the late 1800s.[3][4][5][6][7][8] Squibb Corporation served as a major supplier of medical goods to the Union Army during the American Civil War, providing portable medical kits containing morphine, surgical anesthetics, and quinine for the treatment of malaria (which was endemic in most of the eastern United States
United States
at that time).[9] Bristol-Myers[edit] In 1887, Hamilton College graduates William McLaren Bristol and John Ripley Myers purchased the Clinton Pharmaceutical company
Pharmaceutical company
of Clinton, New York. In 1898, they decided to rename it Bristol, Myers and Company. Following Myers' death in 1899, Bristol changed the name to the Bristol-Myers Corporation. The first nationally recognized product was Sal Hepatica, a laxative mineral salt in 1903. Its second national success was Ipana toothpaste, from 1901 through the 1960s.[10] Other divisions were Clairol (hair colors and haircare) and Drackett (household products such as Windex and Drano). In 1943, Bristol-Myers acquired Cheplin Biological Laboratories, a producer of acidophilus milk in East Syracuse, New York, and converted the plant to produce penicillin for the World War II Allied forces. After the war, the company renamed the plant Bristol Laboratories in 1945 and entered the civilian antibiotics market, where it faced competition from Squibb, which had opened the world's largest penicillin plant in 1944 in New Brunswick, New Jersey.[10][11] Penicillin
Penicillin
production at the East Syracuse plant was ended in 2005, when it became less expensive to produce overseas,[citation needed] but the facility continues to be used for the manufacturing process development and production of other biologic medicines for clinical trials and commercial use.[12] Merger[edit] Bristol-Myers and Squibb merged in 1989, with Bristol-Myers as the nominal survivor. The merged company became Bristol-Myers Squibb. In 1999, President Clinton awarded Bristol-Myers Squibb
Bristol-Myers Squibb
the National Medal of Technology, the nation's highest recognition for technological achievement, "for extending and enhancing human life through innovative pharmaceutical research and development and for redefining the science of clinical study through groundbreaking and hugely complex clinical trials that are recognized models in the industry." 2000 to 2010[edit] In 2002, the company was involved in a lawsuit of maintaining illegally a monopoly on Taxol, its cancer treatment, and it was again sued for the antitrust lawsuit 5 years later, which cost the company $125 million for settlement.[13] The company was involved in an accounting scandal in 2002 that resulted in a significant restatement of revenues from 1999 to 2001. The restatement was the result of an improper booking of sales related to "channel stuffing" as the practice of offering excess inventory to customers to create higher sales numbers. The company has since settled with the United States
United States
Department of Justice and Securities and Exchange Commission, agreeing to pay $150 million while neither admitting nor denying guilt.[14] On October 24, 2002, Bristol-Myers Squibb
Bristol-Myers Squibb
Co. restated earnings downward for parts of 2000 and 2001 while revising this year's earnings upward because of its massive inventory backlog imbroglio that spurred two government investigations.[15] On March 15, 2004, Bristol-Myers Squibb
Bristol-Myers Squibb
Co. adjusted upward its fourth-quarter and full-year 2003 results after reversing an earlier decision about how to deal with accounting errors made in prior years.[16] As part of a Deferred Prosecution Agreement, the company was placed under the oversight of a monitor appointed by the U.S. Attorney in New Jersey. In addition, the former head of the Pharma group, Richard Lane, and the ex-CFO, Fred Schiff, were indicted for federal securities violations. An investigation of the company was made public in July 2006, and the FBI
FBI
raided the company's corporate offices. The investigation centered on the distribution of Plavix and charges of collusion.[17] On September 12, 2006, the monitor, former Federal Judge Frederick B. Lacey, urged the company to remove then CEO Peter Dolan over the Plavix dispute. Later that day, BMS announced that Dolan would indeed step down.[18] The Deferred Prosecution Agreement expired in June 2007 and the Department of Justice did not take any further legal action against the company for matters covered by the DPA. Under CEO Jim Cornelius, who was CEO following Dolan until May 2010, all executives involved in the "channel-stuffing" and generic competition scandals have since left the company. In 2009, a major restructuring involves focusing on the pharmaceutical business and biologic products, along with productivity initiatives and cost-cutting and streamlining business operations through a multi-year program of on-going layoffs. As another cost-cutting measure Bristol-Myers also reduced subsidies for health-care to retirees and plans to freeze their pension plan at the end of 2009.[citation needed] In August, BMS acquired the biotechnology firm Medarex as part of the company's "String of Pearls" strategy of alliances, partnerships and acquisitions.[19] In November, Bristol-Myers Squibb
Bristol-Myers Squibb
announced that it was "splitting off" Mead Johnson Nutrition by offering BMY shareholders the opportunity to exchange their stock for shares in Mead Johnson. According to Bristol-Myers Squibb, this move was expected to further sharpen the company's focus on biopharmaceuticals. BMS is a Fortune 500 Company (#114 in 2010 list). Newsweek's 2009 Green Ranking recognized Bristol-Myers Squibb
Bristol-Myers Squibb
as 8th among 500 of the largest United States
United States
corporations. Also, BMS was included in the 2009 Dow Jones Sustainability North America Index of leading sustainability-driven companies. In October 2010, the company acquired ZymoGenetics, securing an existing product as well as pipeline assets in hepatitis C, cancer and other therapeutic areas. Lamberto Andreotti was named CEO this year; he had previously served as "president and COO responsible for all pharmaceutical operations worldwide."[20] 2011 onward[edit] Bristol-Myers Squibb
Bristol-Myers Squibb
agreed to pay around $2.5 billion in cash to buy Inhibitex Inc. in attempt to compete with Gilead/ Pharmasset
Pharmasset
to produce Hepatitis
Hepatitis
C drugs. The settlement will be finished in 2 months for its Inhibitex's shareholders acceptance of 126 percent premium price of its price over the previous 20 trading days ended on January 6.[21] On June 29, Bristol-Myers Squibb
Bristol-Myers Squibb
extended its portfolio of diabetes treatments when it agreed to buy Amylin Pharmaceuticals
Pharmaceuticals
Inc for around $5.3 billion in cash and will pay $1.7 billion to Eli Lilly
Eli Lilly
to cover Amylin's debt and its obligations to Eli Lilly
Eli Lilly
from ending the collaboration with Amylin. Astra Zeneca, who already collaborates on several diabetes treatments with BMS, will pay $3.4 billion in cash for the rights to develop Amylin's products.[22] Citing major developments and a market capitalization of US$87 billion and stock appreciation of 61.4%, Bristol-Myers Squibb
Bristol-Myers Squibb
was ranked as the best drug company of 2013 by Forbes Magazine.[23] In April 2014, BMS announced its acquisition of iPierian for up to $725 million.[24] In December the company received FDA approval for the use of the PD-1
PD-1
inhibitor nivolumab (Opdivo) in treating patients whose skin cancer cannot be removed or have not responded to previous drug therapies.[25] In February 2015, the company acquired Flexus Biosciences for $1.25 billion as well as initiating a research partnership with Rigel Pharmaceuticals
Pharmaceuticals
which could generate more than $339 million. As part of the deal with Flexus, BMS will gain full rights to Flexus' lead small molecule IDO1-inhibitor, F001287.[26] In March, the company obtained an exclusive opportunity to both licence and commercialise PROSTVAC, Bavarian Nordic's phase III prostate specific antigen targeting cancer immunotherapy. Bavarian Nordic
Bavarian Nordic
will receive an upfront payment of $60 million as well as incremental payments up to $230 million, if the overall survival of test patients exceeds that seen in Phase II tests. Bavarian could also receive milestone payments of between $110 million and $495 million, dependent on regulatory authorization, and these payments have the potential to total up to $975 million.[27] In May 2015, Dr. Giovanni Caforio became CEO of the company;[28] Caforio was formerly the company's COO and succeeded Andreotti upon his retirement.[20] Andreotti subsequently succeeded James Cornelius as executive chairman upon his retirement.[20] In November, the company acquired the cardiovascular disease drug developer Cardioxyl for up to $2.075 billion. The deal strengthens the BMS' critical pipelines with the phase II candidate for acute decompensated heart failure, CXL-1427.[29] In March 2016, the company announced it would acquire Padlock Therapeutics for up to $600 million.[30] In early July, the company announced it would acquire Cormorant Pharmaceuticals
Pharmaceuticals
for $520 million, boosting BMS' onclogy offering through Cormorants monoclonal antibody targeted against interleukin-8.[31] In late February 2017, the Wall Street Journal
Wall Street Journal
and Fortune - among others - reported that activist investor, Carl Icahn, had taken a stake in the company, signalling a potential future takeover[32][33] from the likes of Gilead
Gilead
Sciences.[34] In August the company acquired IFM Therapeutics for $300 million upfront, with contingency payments of $1.01 billion due on certain milestones - allowing BMS to better compete against Merck & Co's cancer rival treatment, Keytruda.[35] Acquisition history[edit] The following is an illustration of the company's major mergers and acquisitions and historical predecessors (this is not a comprehensive list):

Bristol-Myers Squibb

Bristol-Myers Squibb

Squibb Corporation (Founded 1858)

Bristol-Myers (Founded 1887)

Adnexus Therapeutics[36] (Acq 2007)

Bristol-Myers Squibb
Bristol-Myers Squibb
Medical Imaging[37] (Sold to Avista Capital Partners 2007)

ConvaTec[38] (Sold to Avista Capital Partners & Nordic Capital Fund VII 2008)

Kosan Biosciences[39] (Acq 2008)

Medarex (Acq 2009)

Mead Johnson (Spun off 2009)

ZymoGenetics (Acq 2010)

Amira Pharmaceuticals[40] (Acq 2011)

Inhibitex Inc (Acq 2012)

Amylin Pharmaceuticals (Acq 2012 jointly with AstraZeneca)

iPierian (Acq 2014)

Flexus Biosciences (Acq 2015)

Cardioxyl (Acq 2015)

Padlock Therapeutics (Acq 2016)

Cormorant Pharmaceuticals (Acq 2016)[31]

IFM Therapeutics (Acq 2017)

Pharmaceuticals[edit] The following is a list of key pharmaceutical products:[41]

Cardiovascular diseases

Avalide (irbesartan/hydrochlorothiazide) — comarketed with Sanofi Avapro (irbesartan) — comarketed with Sanofi Coumadin (warfarin) Eliquis (apixaban) — comarketed with Pfizer Plavix (clopidogrel) — comarketed with Sanofi Pravachol (pravastatin)

Diabetes
Diabetes
mellitus

Bydureon (exenatide extended-release) — marketed by BMS only in some countries Byetta (exenatide) — marketed by BMS only in some countries, such as Russian Federation Farxiga/Forxiga (dapagliflozin) Glucophage (metformin) — marketed by BMS only in USA Glucophage XR (metformin extended release) — marketed by BMS only in USA Glucovance (glyburide/metformin) — marketed by BMS only in USA Kombiglyze XR/Komboglyze (saxagliptin/metformin extended release) — comarketed with AstraZeneca Onglyza (saxagliptin) — comarketed with AstraZeneca

Infectious diseases, including HIV infection and associated conditions

Atripla
Atripla
(efavirenz/emtricitabine/tenofovir disoproxil fumarate) — comarketed with Gilead
Gilead
Sciences Azactam (aztreonam) Baraclude (entecavir) Daklinza (daclatasvir) Evotaz (atazanavir/cobicistat) Megace (megestrol acetate) Reyataz (atazanavir) Sustiva/Stocrin (efavirenz) Videx (didanosine) Videx EC (didanosine delayed-release) Zerit (stavudine)

Inflammatory disorders

Kenalog-10 (triamcinolone acetonide) Kenalog-40 (triamcinolone acetonide)

Oncology

BiCNU (carmustine) CeeNU (lomustine) Droxia/Hydrea (hydroxycarbamide) Empliciti (Elotuzumab) Erbitux (cetuximab) Etopophos (etoposide) Ixempra (ixabepilone) Lysodren (mitotane) Megace (megestrol acetate) Opdivo (nivolumab) is a programmed death receptor blocking antibody used for the treatment of unresectable or metastatic melanoma and metastatic squamous non-small-cell lung carcinoma. In contrast to traditional chemotherapies and targeted anti-cancer therapies, which exert their effects by direct cytotoxic or tumor growth inhibition, nivolumab acts by inducing the immune system to attack the tumor.[42] Sprycel (dasatinib) Taxol (paclitaxel). At one time, BMS held the solitary contract to harvest the bark of endangered yew trees on United States
United States
territory for the manufacture of chemotherapy drug paclitaxel (Taxol). Current paclitaxel production comes from renewable sources.[citation needed] BMS also held the original paclitaxel license, but there are now multiple generic producers.[43] Vumon (teniposide) Yervoy (ipilimumab)

Psychiatry

Abilify (aripiprazole comarketed with Otsuka Pharmaceutical)

Rheumatic disorders

Orencia (abatacept)

Transplant rejection

Nulojix (belatacept)

Out of production[edit]

Sal Hepatica Ipana

Divested brands[edit] (Former Bristol-Myers brands, now divested)

Bufferin Excedrin [44] Ban Deodorant Vitalis (hair tonic) [45] Ammens (medicated power) Final Net (hair spray) Comtrex (cold relief capsules) Keri (lotion) [46]

Products under development[edit] The following is a selective list of investigational products under development, as of 2015:[47]

Beclabuvir
Beclabuvir
(BMS-791325) — phase III BMS-906024
BMS-906024
— phase I BMS-955176
BMS-955176
— phase II Brivanib alaninate
Brivanib alaninate
(BMS-582664) — development terminated Elotuzumab
Elotuzumab
(BMS-901608) — phase III Fostemsavir
Fostemsavir
(BMS-663068) — phase III Lirilumab (BMS-986015) Lulizumab pegol (BMS-931699) — phase II Necitumumab
Necitumumab
— development terminated PROSTVAC+

See also[edit]

Biotech and pharmaceutical companies in the New York metropolitan area

Notes and references[edit]

^ "US SEC: Form 10-K Bristol-Myers Squibb
Bristol-Myers Squibb
Company". U.S. Securities and Exchange Commission. Retrieved February 17, 2018.  ^ " Bristol-Myers Squibb
Bristol-Myers Squibb
and Biocon's Syngene open new R&D Facility at Biocon Park". Archived from the original on 29 September 2012. Retrieved 16 May 2012.  ^ Hollopeter, W.C. (January 8, 1885). "Inverse Type of Temperature in Typhoid Fever, with a Report of Two Cases — Temperature Peculiarities in Epidemics, with a Report of Seven Cases in One Family". Boston Medical and Surgical Journal. 112: 28–32. doi:10.1056/NEJM188308301090903. Retrieved 2014-11-25. The writer noticed (in December, 1882) the important fact that when common or Japan camphor and crystallized carbolic acid are mixed together and subjected to heat, a colorless liquid would be the result. The only reference he finds so far with regard to this reaction occurs in the very excellent and valuable scientific publication of Dr. E. R. Squibb, " Ephemeris of Materia Medica", etc., on page 673, vol. ii., No. 5, where a brief allusion appears under the appellation of Compound Alum Powder. Dr. F. R. Squibb, however, in a letter to the writer states that he has " several times before heard of this reaction between phenol and camphor.  ^ Bolles, William (August 30, 1883). "REPORT ON MATERIA MEDICA AND PHARMACY". Boston Medical and Surgical Journal. 109: 195–196. doi:10.1056/NEJM188308301090903. Retrieved 2014-11-25. Dr. Squibb is publishing in his Ephemeris a long and careful criticism upon the new Pharmacopoeia, four installments of which have already appeared, and are full of sound observation, and rich in practical pharmaceutical knowledge.  ^ Worthen, Dennis (2003). " Edward Robinson Squibb
Edward Robinson Squibb
(1819–1900): Advocate of Product Standards". Journal of the American Pharmacists Association. 46: 754–758. doi:10.1331/1544-3191.46.6.754. Retrieved 2014-11-25.  ^ Blake, J.B. (1899). "Administration of Ether at the Boston City Hospital". Boston Med Surg J. 141: 312–314. doi:10.1056/NEJM189909281411303. Until within six months Squibb's other has been exclusively used at the Boston City Hospital. Recently .MeliiHTéift's ether has been tried, ¡uni has given fair satisfaction ; Squibb's is still preferred by most of the house officers.  ^ Brown, W.S. (1885). "Forty Year's Experience in Midwifery". Boston Medical and Surgical Journal. 112: 241. doi:10.1056/nejm188503121121101. One reason why ergot has fallen into disrepute is the poor quality of many specimens offered for sale. Dr. Squibb's aqueous extract rarely disappoints me.  ^ Blodgett, Albert (October 27, 1887). "Reports of Societies: Massachusetts Medical Society. Suffolk District. Section for Clinical Medicine, Pathology and Hygiene". Boston Medical and Surgical Journal. 117: 408–413. doi:10.1056/NEJM188710271171706. Retrieved 2014-11-25. Dr. Farlow replied that he has had no trouble with any of the standard preparations of this drug, as manufactured by responsible firms. He mentioned Parke, Davis, & Co., Squibb, Metcalf, and a few others, whose preparations he had found to be reliable, and of uniform character.  ^ Smith. Medicines for the Union Army: the United States
United States
Army laboratories during the Civil War.  Accessed 2014-11-25. ^ a b Bert Rosenbloom, Marketing Channels, Bristol-Myers Squibb, 2011, page 609 ^ "Bristol-Myers Squibb". Drugwatch. February 25, 2016. Retrieved November 14, 2016.  ^ Bristol-Meyers Squibb, Syracuse, New York ^ "Bristol hit with antitrust suit". CNN. June 4, 2002. Retrieved Jul 10, 2013.  ^ " Bristol-Myers Squibb
Bristol-Myers Squibb
Company : Lit. Rel. No. 18822" (Press release). US Securities and Exchange Commission. August 6, 2004. Retrieved May 9, 2015. Bristol-Myers inflated its results primarily by: (1) stuffing its distribution channels with excess inventory near the end of every quarter in amounts sufficient to meet sales and earnings targets set by officers ("channel-stuffing")  ^ "Bristol-Myers to restate earnings as third quarter profits plunge".  ^ "Bristol-Myers restates results upward due to accounting errors".  ^ Business Report Archived 17 August 2007 at the Wayback Machine., July 31, 2006. Retrieved September 7, 2006. Archived at ^ CNN.com, September 12, 2006. Retrieved September 12, 2006 ^ https://finance.yahoo.com/news/BristolMyers-Squibb-to-bw-571310065.html?x=0&.v=1 ^ a b c Staff (15 February 2015). "BMS CEO Andreotti to Retire; COO named as Successor". Genetic Engineering & Biotechnology
Biotechnology
News (paper). 35 (4). p. 6.  ^ "Bristol Buys Inhibitex for $2.5 Billion to Compete in Hepatitis". January 8, 2012.  ^ "Bristol-Myers to buy Amylin for about USD 5.3 billion". Reuters. June 30, 2012.  ^ Herper, Matthew (December 31, 2013). "Grading Pharma in 2013". Forbes.  ^ "Bristol-Myers to buy iPierian". Genetic ngineering & biotechnology news. April 29, 2014.  ^ Anna Edney (22 December 2014). "Bristol-Myers Drug Wins U.S. Approval to Treat Advanced Melanoma". Bloomberg.com.  ^ "GEN – News Highlights:BMS Deals Add to its Immuno-Oncology Portfolio". GEN.  ^ " Bavarian Nordic
Bavarian Nordic
Could Tally up to $975 Million in Prostate Cancer Deal with BMS – GEN News Highlights – GEN". GEN.  ^ Johnson, Linda A. "New CEO Takes Over Evolving Drugmaker Bristol-Myers Squibb". ABC News. Retrieved 6 May 2015.  ^ "BMS to Buy Cardioxyl for Up to $2.075B". GEN.  ^ "BMS to Acquire Padlock Therapeutics for Up to $600M". GEN.  ^ a b "BMS Snags Cormorant Pharmaceuticals
Pharmaceuticals
for Up to $520M (online title: BMS Acquires Cormorant Pharmaceuticals
Pharmaceuticals
for Up to $520M)". News: Industry Watch (online: GEN News Highlights). Genetic Engineering & Biotechnology
Biotechnology
News. 36 (14): 10. August 2016.  ^ " Bristol-Myers Squibb
Bristol-Myers Squibb
Shares Just Spiked on Reports of a Carl Icahn Stake". Fortune. Retrieved 23 May 2017.  ^ Benoit, David; Rockoff, Jonathan D. (22 February 2017). "Carl Icahn Takes Stake in Bristol-Myers Squibb". Retrieved 23 May 2017 – via www.wsj.com.  ^ "Making (good) deals is hard to do, Gilead
Gilead
CEO says, but he's working on it - FiercePharma". www.fiercepharma.com. Retrieved 23 May 2017.  ^ Editorial, Reuters. "Bristol-Myers to buy IFM Therapeutics to strengthen cancer pipeline".  ^ " Bristol-Myers Squibb
Bristol-Myers Squibb
to Acquire Adnexus Therapeutics". bms.com.  ^ "Avista Capital Partners Agrees to Acquire Bristol-Myers Squibb Medical Imaging for Approximately $525 Million". bms.com.  ^ "Nordic Capital Fund VII and Avista Capital Partners Agree to Acquire ConvaTec Business for approximately $4.1 Billion". bms.com.  ^ " Bristol-Myers Squibb
Bristol-Myers Squibb
to Acquire Kosan Biosciences". bms.com.  ^ " Bristol-Myers Squibb
Bristol-Myers Squibb
to Acquire Amira Pharmaceuticals". bms.com.  ^ "Selected Products of Bristol-Myers Squibb". © 2015 Bristol-Myers Squibb Company. Retrieved 30 May 2015.  ^ Johnson DB, Peng C, Sosman JA (2015). " Nivolumab
Nivolumab
in melanoma: latest evidence and clinical potential". Ther Adv Med Oncol. 7 (2): 97–106. doi:10.1177/1758834014567469. PMC 4346215 . PMID 25755682.  ^ "Generic Taxol Availability". drugs.com.  ^ "Bristol-Myers puts U.S. consumer brands on block - Jan. 12, 2005".  ^ " Bristol-Myers Squibb
Bristol-Myers Squibb
to Divest Three Consumer Brands". Bristol-Myers Squibb
Bristol-Myers Squibb
Company. 21 September 1998.  ^ " Bristol-Myers Squibb
Bristol-Myers Squibb
Plans To Divest U.S. And Canadian Consumer Medicines Business - Business Wire". 12 January 2005.  ^ "Bristol-Myers Squibb: the Pipeline". © 2015 Bristol-Myers Squibb Company. Retrieved 30 May 2015. 

External links[edit]

" Bristol-Myers Squibb
Bristol-Myers Squibb
donates $6.9 million to benefit cancer patient". Drugstorenews.com. 

Business data for Bristol-Myers Squibb: Google Finance Yahoo! Finance Reuters SEC filings

v t e

Pharmaceutical companies of the United States

Current

Abbott Laboratories Acorda Therapeutics Aderis Pharmaceuticals Advaxis Alcon Alexion Pharmaceuticals Alkermes Allergan Alnylam Amgen Avax Technologies Baxter International BioCryst Pharmaceuticals Biogen Bioverativ Biovest Biovista Bristol-Myers Squibb Century Pharmaceuticals Ceragenix Pharmaceuticals Combe Incorporated CytoSport CytRx Danco Laboratories Eli Lilly
Eli Lilly
and Company Endo Pharmaceuticals

Par Pharmaceutical

Galena Biopharma Genentech Gilead
Gilead
Sciences Ionis Pharmaceuticals Institute for OneWorld Health Intercept Pharmaceuticals Johnson & Johnson

Ethicon Janssen Biotech McNeil Consumer Healthcare Ortho-McNeil Pharmaceutical

Kinetic Concepts Mallinckrodt McKesson Corporation Melinta Therapeutics (formerly Rib-X Pharmaceuticals) Melior Discovery Mentholatum Merck & Co. Myriad Genetics Northwest Biotherapeutics Norwich Pharma Services NovaBay Pharmaceuticals Ovation Pharmaceuticals Perrigo Pfizer

Hospira Searle

Pharmaceutical Product Development Prasco Laboratories Procter & Gamble Proteon Therapeutics Purdue Pharma Quark Pharmaceuticals Regeneron Repros Therapeutics RespireRx Sarepta Therapeutics Savage Laboratories Sheffield Pharmaceuticals Spectrum Pharmaceuticals Tec Laboratories Titan Pharmaceuticals Trevena Inc Upsher-Smith Laboratories Ventria Bioscience Vertex Pharmaceuticals West Pharmaceutical Services

Former

Alza Amylin Pharmaceuticals ARIAD Pharmaceuticals Biolex Bradley Pharmaceuticals CancerVax Cephalon CoTherix Covance Covidien Cubist Pharmaceuticals Cutter Laboratories DNAPrint Genomics Epix Pharmaceuticals Forest Laboratories Genta ImClone Systems ISTA Pharmaceuticals King Pharmaceuticals KV Pharmaceutical Leiner Health Products Martek Biosciences Corporation S. E. Massengill Company Miles Laboratories Naurex Nereus Pharmaceuticals Nuvelo Organon International Ortho Pharmaceutical OSI Pharmaceuticals Parke-Davis Qualitest Schering-Plough Smith, Kline & French Sterling Drug Tanox TAP Pharmaceutical Products Trubion Upjohn Verus Pharmaceuticals Vion Pharmaceuticals, Inc. ViroPharma Wyeth Zonite Products Corporation

List of pharmaceutic